Q. WHAT IS PLECHNER'S SYNDROME?
"PLECHNER'S SYNDROME IS DISTINCTLY DIFFERENT FROM ADDISON'S
SYNDROME AND CUSHING'S SYNDROME. IT IS THE REASON FOR THE MEDICAL
ICE AGE." PLECHNER'S SYNDROME IS A DEFICIENCY OF ACTIVE (WORKING)
CORTISOL FROM THE MIDDLE LAYER ADRENAL CORTEX, EITHER
FROM A TRUE DEFICIENCY, A BINDING, OR THE PRODUCTION OF A DEFECTIVE
CORTISOL. THE MINERAL CORTICOID FROM THE FIRST LAYER, AND THE
SEX HORMONES FROM THE INNER LAYER, ARE ALSO NORMAL. ADDISON'S
SYNDROME DEALS WITH THE FIRST LAYER OF THE ADRENAL CORTEX
WHERE THE HORMONE ALDOSTERONE IS PRODUCED WHICH BALANCES SODIUM AND
POTASSIUM LEVELS. CUSHING'S SYNDROME IS AN EXCESS PRODUCTION OF
ACTIVE (WORKING) CORTISOL DUE TO A PITUITARY TUMOR, AN ADRENAL
TUMOR, OR JUST AN INCREASE IN THE MIDDLE LAYER OF THE ADRENAL
CORTEX CALLED, "HYPERTROPHY". ORIGINALLY, CUSHING'S SYNDROME WAS
REPORTED BY DR. HARVEY CUSHING WHICH WAS RELATED TO A PITUITARY
TUMOR THAT PRODUCED EXCESS AMOUNTS OF ACTH (ADRENOCORTICOTROPIC
HORMONE) WHICH IN TURN CAUSED THE MIDDLE LAYER TO PRODUCE TOO MUCH
ACTIVE (WORKING) CORTISOL.
Q. WHAT IS THE MEDICAL ICE AGE?
The MEDICAL ICE AGE relates to the gradual breakdown of
ourselves, our animals, and our earth. As this gradual breakdown is
occurring, a concentration of predisposing factors of poor health
are being created. Not only are we seeing entire families of people
developing allergies, auto-immunity, and cancer, but we are also
seeing even a faster progression of diseases in our animals due to
indiscriminant breeding, and breeding without function.
The lack of concern for our earth has
further allowed for environmental breakdown, contamination of our
soils and waters, and the development of an unstable atmosphere. We
are potentially destroying our own life line. With this present day
destruction, a potentially dangerous cortisol deficiency is being
created in our bodies which allows the immune system not to protect
people and animals, but instead allows the loss of recognition of
the body's own tissue by these cells, resulting in allergies,
auto-immunity, and cancer. This is called, PLECHNER'S SYNDROME.
The identification and control of this syndrome may slow down the
MEDICAL ICE AGE which threatens our existence. For more
information about PLECHNER'S SYNDROME and the MEDICAL ICE
AGE, please go to our Library.
Q. IN WHAT OTHER WAYS IS PLECHNER'S SYNDROME
DIFFERENT FROM ADDISON'S SYNDROME AND CUSHING'S SYNDROME?
SYNDROME involves the MIDDLE
LAYER adrenal cortex where ESTROGEN AND ANDROGEN
hormones are produced. ADDISON'S SYNDROME involves the FIRST
LAYER of the adrenal cortex where the hormone ALDOSTERONE
is produced which balances Sodium and Potassium levels. CUSHING'S
SYNDROME involves the MIDDLE LAYER adrenal cortex
where the hormone CORTISOL is produced which is necessary for life.
CUSHING'S SYNDROME is the production of too much active (working)
cortisol. (A more comprehensive definition of PLECHNER'S SYNDROME
will follow *below, and can be located on drplechner.com
under, "PLECHNER'S SYNDROME".
SYNDROME: is an accumulation of a
widely varying group of clinical signs and symptoms that
characterize any of a variety of disease abnormalities or conditions
which create a specific identifiable pattern in specific hormone and
antibody levels in blood serum of several species of mammals. This
syndrome is due to a damaged MIDDLE LAYER adrenal cortex because of
a genetic predisposition, environmental toxins, or aging. This
damaged MIDDLE LAYER adrenal cortex in turn causes a reduction in
active (working) cortisol, resulting in an elevated amount of
estrogen to be produced by the INNER LAYER adrenal cortex. Normal
amounts of cortisol may be present, however this cortisol can be
defective or bound and the same estrogenic effect may occur. The
cortisol and estrogen imbalance usually presents itself as an
altered immunity status with antibody depression present. This not
only may result in malabsorption from the intestines, but also
allows the immune cells to lose recognition of the body's own tissue
and thus attack their own host. These changes in glandular
performance allow for a variety of medical effects to occur anywhere
from allergies, irritable bowel disease, autoimmunity, uncontrolled
tissue growth, and cancer.
Q. WHAT IS CORTISOL?
is a hormone that is secreted from the MIDDLE LAYER of the adrenal
cortex. It helps the cells in the body to break down fat and
proteins into their basic blocks called, "carbohydrates". It is also
involved in reducing inflammation in the body. This is probably the
most important hormone in the body, and the most feared when medical
replacement is suggested.
Q. WHAT ARE THE ADRENAL GLANDS?
A. The ADRENAL
GLANDS were originally called the SUPRARENAL GLANDS, because they
sit on top of each kidney. They therefore consist of a right and
left gland, and are covered by the overlying fatty capsule from the
kidney. The cortex of the gland consists of three layers. The first
layer produces the hormone ALDOSTERONE, which is not only
responsible for electrolyte balance, but works with a hormone from
the kidney to regulate blood pressure. The second, or MIDDLE LAYER,
produces CORTISOL which has a number of functions and works closely
with the pituitary gland. The third layer, or INNER LAYER, produces
both ESTROGEN and a male hormone called, ANDROGEN.
Q. WHAT IS A SYNDROME?
A. A SYNDROME is an accumulation of a
group of clinical signs and symptoms that characterize a disease
abnormality or condition which may create a specific identifiable
Q. WHAT IS A HORMONE?
A. A HORMONE is
a chemically complex substance that is manufactured in an organ or
one part of the body that either begins or regulates the function of
a group of cells, or a specific organ, that resides in a different
location in the body. These substances (HORMONES) are secreted by
glands called, ENDOCRINE GLANDS, and travel through the blood stream
to their target organs.
Q. WHAT IS ESTROGEN?
ESTROGEN is a hormone that is part of a group of estrogenic
compounds. With normal amounts of ESTROGEN production present, this
hormone helps to develop female secondary sex characteristics in the
animal. This hormone can be produced by the ovaries, THE INNER
LAYER OF THE ADRENAL CORTEX, testes and placenta. Other
forms of ESTROGEN can also be ingested from fruits, vegetables and
Q. HOW DOES EXCESS ESTROGEN AFFECT MY IMMUNE SYSTEM?
CORTISOL allows for the pituitary gland to over-stimulate the
production of excess ESTROGEN. This excess estrogen not only causes
an inflammation of the lining cells of all arteries in the body,
including those arteries to the intestines, but causes the B and T
immune cells to become deregulated. It also causes the B cell to
reduce its production of antibodies. This in turn causes further
turmoil in the gut. When regulated, the B cell protects the body
against bacteria and makes protective antibodies to vaccines and
other intruders. When the T cell is regulated it protects the body
against viruses and plant invaders like yeast and fungi. The
hormonal antibody deregulation is why all of these intruders can
cause medical effects (illnesses and diseases). Many substances
are used to combat these EFFECTS, but while this is being done, the
CAUSE must also be corrected, otherwise the EFFECTS will continue.
The continuous use of antibiotics and anti-yeast and fungal
medications alone will not correct the problem since they can only
be managed effectively through replacement and correction of the
hormonal antibody imbalance.
Furthermore, when there is an excess of estrogen
being produced (or present), it may also cause the following:
- A chemical binding of both thyroid hormones (T3 andT4).
- A chemical binding of active (working) CORTISOL and this in
turn disallows or prevents the transference of storage thyroid
(T4) into active thyroid (T3) in the body.
- The deregulation of the immune system which causes it not
only to be unable to PROTECT the body, but to further lose
recognition of self tissue and thus be able to DESTROY the
normal tissues in the body.
- It also causes the immune system to decrease antibody
production for protection and from creating protective
antibodies from natural invaders and vaccines.
- It also can lead to an inflammation of the cells lining all
the arteries in the body (ENDOTHELIAL CELLS). Inflammation of
the arteries may lead to not only strokes and heart attacks, but
also to any disease that might respond to a decreased blood flow
and lack of proper oxygenation.
Q. WHEN CORTISOL AND ESTROGEN LEVELS ARE IMBALANCED,
WHY DOES THE IMMUNE SYSTEM MALFUNCTION?
A. Based upon
the review of thousands of serum tests and clinical evidence, the
immune system does appear to malfunction.
When we see excess ESTROGEN and defective or
insufficient CORTISOL we also see:
- Reduced numbers of specific immunoglubulins, such as IgA.
- Frequent clinical symptoms of auto-immune disease.
- Reduced IgA levels in serum. Immunoglubulins: IgA, IgM, and
IgG in particular are tested for and closely monitored.
- Clinical evidence of new antibody production while the
animal is still in endocrine imbalance as demonstrated by new
food sensitivities and allergies presented as symptoms during
the period of imbalance.
There is strong clinical evidence for immune
system deregulation, but presently no clear understanding of the
mechanism for this deregulation. There is ample clinical evidence of
a return to a normally functioning immune system when the animal's
tested hormone levels return to mid-range normal levels.
Q. HOW COULD MY ADRENAL GLANDS BE INJURED, AND COULD
THEY BE GENETICALLY DEFECTIVE?
A. There is the
possibility that your adrenal glands could be damaged by
environmental pollutants and toxins, through administration of
vaccines, anesthesia, antibiotics, chemotherapy or any chemical
administered to the body, and also due to aging. Defects can also
occur in offspring having been passed down from the parents.
THE MOST FRAGILE LAYER THAT IS MOST
EASILY ADVERSELY AFFECTED IS THE MIDDLE LAYER OF THE ADRENAL CORTEX
AND ITS PRODUCTION OF ACTIVE (WORKING) CORTISOL.
Q. WHAT CAN PLECHNER'S SYNDROME POTENTIALLY DO TO
THE HEALTH OF MYSELF OR MY PET?
SYNDROME may manifest as symptoms of
conditions such as, minor chronic disorders like allergies, to major
catastrophic diseases such as autoimmunity, uncontrolled tissue
growth and cancer. These may all occur due to any event that causes
damage to the MIDDLE LAYER of the adrenal cortex, and the resultant
loss of production of ACTIVE (WORKING) CORTISOL. PLECHNER'S
SYNDROME can develop in early life, midlife, old age, at
virtually any time.
Q. CAN YOU GIVE ME MORE SPECIFICS AS TO WHY
PLECHNER'S SYNDROME IS DISTINCTLY DIFFERENT FROM OTHER DISEASES OF
THE ADRENAL CORTEX SUCH AS CUSHING'S SYNDROME OR ADDISON'S SYNDROME?
SYNDROME DESCRIBES A DEFICIENCY IN THE PRODUCTION OF CORTISOL FROM
THE MIDDLE LAYER ADRENAL CORTEX AND ITS INABILITY TO PROVIDE
ACTIVE (WORKING) CORTISOL WHICH IS THE UNDERLYING CAUSE OF
PLECHNER'S SYNDROME AND THE MEDICAL ICE AGE.
This shortage of active (working) cortisol leads to a domino effect
through the deregulation of thyroid hormones leading to the
production of excess ESTROGEN and the deregulation of the immune
system and all of the diseases and maladies this resulting faulty
immune system creates. NOTE: The diseases are remarkably similar in
man and animals.
CUSHING'S SYNDROME deals with an EXCESS production
of ACTIVE (WORKING) CORTISOL. This excess production, no matter
whether it is endogenous (from within the body) or exogenous (from
outside the body most likely through ingestion of certain foods,
plastics, contaminated water, and medications), may cause clinical
symptoms or clinical signs. The side effects of this EXCESS ACTIVE
(WORKING) CORTISOL may differ slightly in man and animal. In man
what is usually observed is an increase in water consumption,
retention, weight gain and swelling in the face shoulders, legs, and
ankles. Loss of libido and muscle integrity may also occur. Other
effects can be studied on the internet. In canines (dogs), CUSHING'S
SYNDROME often presents itself by symptoms such as severe intake of
water and increased urine that is not concentrated correctly. There
is often sagging of the stomach muscles, and loss of hair without
itching. Again, other effects may be studied on the internet.
ADDISON'S SYNDROME is mainly concerned with a
deficiency in the first layer of the adrenal cortex and its REDUCED
production of ALDOSTERONE, a mineral corticoid hormone. This
shortage may lead to an electrolyte deficiency between SODIUM and
POTASSIUM in the blood. Often, this ALDOSTERONE shortage causes
vomiting, diarrhea, muscle weakness and a heart that is reduced in
size and may stop in contraction. Many other clinical symptoms and
signs can be studied on the internet for both man and for dogs.
The human healthcare professionals have written
that ADDISON'S SYNDROME may be due to a deficiency of regulatory
hormones from ALL THREE LAYERS of the adrenal cortex. The veterinary
health care professionals believe that ADDISON'S SYNDROME is the
result of a deficiency in hormone production from TWO LAYERS of the
adrenal cortex, the FIRST LAYER and SECOND LAYER. ADDISON'S SYNDROME
is believed to be either a TWO LAYER OR THREE LAYER adrenal
Therefore as a comparison, CUSHING'S SYNDROME is
due to EXCESSIVE production of ACTIVE (WORKING) CORTISOL.
is due to REDUCED amounts of ACTIVE (WORKING) CORTISOL, with normal
blood serum levels of SODIUM and POTASSIUM which mean the first
layer of the adrenal gland is normal. The production of excessive
adrenal estrogen further confirms a normal third layer adrenal
The fact that these hormones (ALDOSTERONE
and ADRENAL ESTROGEN) are present relates to whether the CORTISOL
and THYROID HORMONES are working, and not the ESTROGEN and
ALDOSTERONE, otherwise the electrolytes and the antibodies would not
be working. The comparative levels refer to the CORTISOL and
IMMUNOGLUBULINS and this is why it is so important to do comparative
levels, including those secretions which are regulated by active
(working) hormone. This is why
testing for PLECHNER'S SYNDROME is so important. The reason
for the development of salivary tests and twenty-four hour urine
tests were to measure hormones in these fluids and determine if
those hormones that were present are active or bound. It is also
very easy to determine this by comparing serum results with those in
saliva and urine.
Q. HOW DO I DO THE BLOOD TEST?
A. First of all
you will need to have your heath care professional send you or your
pet to a laboratory, clinic, or hospital for a blood draw.
drplechner.com has all the details on handling the sample, where
to send it, and how to ship it so that the sample arrives in a
Q. WHY DO I NEED TO USE THE LABORATORY THAT YOU
A. This is one
of the few laboratories in the United States that can do a TOTAL
total estrogen, and knows how the serum sample needs to be prepared
for shipping and processing. I have used four laboratories over
forty years and I have learned that if these tests are not done
correctly, I cannot assist your veterinarian or physician
effectively, and I do not want the "extra mile that you have
travelled" in attempting to get a diagnosis to be a health care
disappointment for either you or for your pet. Please note that I am
NOT compensated in any way by the use of this laboratory.
Q. HOW DOES A VETERINARIAN OR PHYSICIAN INTERPRET
SERUM TESTS FOR PLECHNER'S SYNDROME?
A. There is a
contact button on drplechner.com which is available for
consultation with your health care professional. Just push the
Q. IS THERE TREATMENT AVAILABLE? IF SO, HOW DO I GET
A. There will
always be treatment available to you through your own health care
professional. I will be more than glad to suggest therapy based upon
the test results while also suggesting any nutritional or dietary
changes that may be helpful. This treatment program is not only set
up to correct hormonal imbalances, but to also look at foods,
enzymes, nutraceuticals and availability of nutrients to the body
via the gut. The entire program is designed to be "WHOLEISTIC".
Remember, many healthcare professionals will treat the EFFECTS of
the illness or disease, but not the ROOT CAUSE cause of it.
Q. ARE STERIOD AND HORMONE REPLACEMENT THERAPIES
SAFE, ESPECIALLY FOR LONG-TERM USE FOR ANIMALS AND FOR HUMANS?
A. Please keep
in mind that THE MOST IMPORTANT HORMONE IN THE BODY IS
CORTISOL AND IT SHOULD NOT BE FEARED BY PATIENTS OR THE MEDICAL
COMMUNITY. In correcting the Endocrine-Immune Imbalance
caused by PLECHNER'S SYNDROME
USING CORTISOL REPLACEMENT THERAPY TO REPLACE THE BODY'S OWN
NATURALLY OCCURING PRODUCTION OF WORKING CORTISOL, COUPLED WITH
THYROID REPLACEMENT THERAPY, WILL GUARANTEE THAT THE SMALL AMOUNT OF
CORTISOL IS UTILIZED AND BROKEN DOWN BY THE BODY IN A TWENTY-FOUR
HOUR PERIOD. THYROID REPLACEMENT THERAPY MUST BE USED IN CONJUNCTION
WITH CORTISOL REPLACEMENT THERAPY TO ENSURE THAT THERE IS NO
RESIDUAL CORTISOL THAT WOULD BUILD UP AND BECOME AN OVERDOSE.
Please also keep in mind PLECHNER'S SYNDROME,
THE ROOT CAUSE OF THE ENDOCRINE-IMMUNE IMBALANCE, DEMONSTRATES AN
IMBALANCE BETWEEN A LACK OF WORKING CORTISOL AND EXCESS ESTROGEN.
THIS IMBALANCE NOT ONLY DEREGULATES THE THYROID, BUT ALSO
DEREGULATES THE IMMUNE SYSTEM AND IS THERBY THE ROOT CAUSE OF
CATASTROPHIC ILLNESSES AND DISEASES WHICH INCLUDE ALLERGIES,
AUTO-IMMUNITY, AND CANCER.
FOOD SENSITIVITIES WILL UNDERMINE THE SUCCESS OF
THE TREATMENT PLAN.
Remember, it is possible
return PLECHNER'S SYNDROME hormone levels to normal ranges
with oral medications, but if you, or your pet, are still showing
signs of problems, you are fighting an existing food sensitivity.
Normally an injection of a cortisol replacement can be given to the
patient with PLECHNER'S SYNDROME, and if in 2 to 3 days there
is no improvement, a dietary change is indicated. drplechner.com
may help you with this. If food sensitivities are present, DO NOT
keep trying different foods because without properly identifying
PLECHNER'S SYNDROME in the patient, the deregulated immune cells
will make antibodies to these foods, and these new antibodies will
always react to those foods even after you have corrected the
mechanism of immune imbalance due to the
GENETIC CONCERNS: RECOMMENDATIONS FOR PREGNANCY
PLANNING FOR BOTH ANIMALS AND FOR HUMANS.
In animals it is very easy to
test the parents to see if their offspring will be normal. With
PLECHNER'S SYNDROME, if both parents are deficient in the same
area the deficiency will usually be concentrated in their offspring.
This is not to say do not breed these animals, it is to say do not
breed them to each other. Both animal parents can be off in
different areas and dilute out their problem in their offspring. Dr.
Plechner has done this for many years and has shown conscientious
breeders how to develop healthy pets for the future thereby avoiding
a MEDICAL ICE AGE.
Obviously with people, this
is a different situation. What people can do however, is to do the
PLECHNER'S SYNDROME test, determine what they will be passing
on to their child, and as soon as the infant's maternal antibodies
have disappeared, check the infant for any imbalance as a
preventative and get these imbalances corrected before any of the
juvenile diseases begin. The test will also indicate whether the
infant will be able to successfully receive vaccines and make
protective antibodies without a severe reaction occurring.
Website content text, Copyright, Dr. Alfred J. Plechner, 2008,
All Rights Reserved.
Dr. Alfred J. Plechner, DVM and Healthy Pet Network
I am happy to make suggestions to you and
your healthcare professional, but please realize I cannot diagnose, prescribe,
or treat. You and your health care professional
will decide if my suggestions should be implemented or not. Remember your
healthcare professional is totally in charge of helping you and your pet. If
there is anything I can do to help, through suggestions only, I would be more
than happy to be involved.